Publication的問題，透過圖書和論文來找解法和答案更準確安心。 我們挖掘到下列精選懶人包

Function Spaces, 2

為了解決Publication的問題，作者Pick, Lubos,Musil, Vit,Kufner, Alois 這樣論述：

The series is devoted to the publication of high-level monographs which cover the whole spectrum of current nonlinear analysis and applications in various fields, such as optimization, control theory, systems theory, mechanics, engineering, and other sciences. One of its main objectives is to mak

e available to the professional community expositions of results and foundations of methods that play an important role in both the theory and applications of nonlinear analysis. Contributions which are on the borderline of nonlinear analysis and related fields and which stimulate further research a

t the crossroads of these areas are particularly welcome. Editor-in-ChiefJürgen Appell, Würzburg, Germany Honorary and Advisory EditorsCatherine Bandle, Basel, SwitzerlandAvner Friedman, Columbus, Ohio, USAManuel del Pino, Bath, UK, and Santiago, ChileMikio Kato, Nagano, JapanWojciech Kryszewski, To

ruń, PolandVicenţiu D. Rădulescu, Kraków, PolandSimeon Reich, Haifa, Israel Please submit book proposals to Jürgen Appell. Titles in planning includeIreneo Peral Alonso and Fernando Soria, Elliptic and Parabolic Equations Involving the Hardy-Leray Potential (2020)Cyril Tintarev, Profile Decompositio

ns and Cocompactness: Functional-Analytic Theory of Concentration Compactness (2020)Takashi Suzuki, Semilinear Elliptic Equations: Classical and Modern Theories (2021)

Publication進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Publication的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Function Spaces, 1

為了解決Publication的問題，作者Pick, Lubos,Musil, Vit,Kufner, Alois 這樣論述：

The series is devoted to the publication of high-level monographs which cover the whole spectrum of current nonlinear analysis and applications in various fields, such as optimization, control theory, systems theory, mechanics, engineering, and other sciences. One of its main objectives is to mak

e available to the professional community expositions of results and foundations of methods that play an important role in both the theory and applications of nonlinear analysis. Contributions which are on the borderline of nonlinear analysis and related fields and which stimulate further research a

t the crossroads of these areas are particularly welcome. Editor-in-ChiefJürgen Appell, Würzburg, Germany Honorary and Advisory EditorsCatherine Bandle, Basel, SwitzerlandAvner Friedman, Columbus, Ohio, USAManuel del Pino, Bath, UK, and Santiago, ChileMikio Kato, Nagano, JapanWojciech Kryszewski, To

ruń, PolandVicenţiu D. Rădulescu, Kraków, PolandSimeon Reich, Haifa, Israel Please submit book proposals to Jürgen Appell. Titles in planning includeIreneo Peral Alonso and Fernando Soria, Elliptic and Parabolic Equations Involving the Hardy-Leray Potential (2020)Cyril Tintarev, Profile Decompositio

ns and Cocompactness: Functional-Analytic Theory of Concentration Compactness (2020)Takashi Suzuki, Semilinear Elliptic Equations: Classical and Modern Theories (2021)

強化資訊通信系統的安全機制設計之研究

為了解決Publication的問題，作者林㒥祥 這樣論述：

隨著資訊技術的發展，迄今資訊安全已是全球性的問題，國家對資訊基礎建設的依賴越來越重，隨著網路興起使近年來網路上不斷發生資安事件，除了嚴重影響個人及企業，對國防資訊通信系統的安全也是一大隱憂，隨著各系統介接整合，單一身分認證機制的防護不足，機敏資訊易遭竊取、偽冒或破解等重要議題，使得如何強化資訊網路安全性，已成為當前國軍重視考量之課題。為提升系統的安全性，本研究設計將區塊鏈及智能合約導入訊息交換系統，利用其不可竄改及條件執行、去中心化等特性，由智能合約管控，直至設定條件滿足後，由智能合約驗證身分並自動執行電子訊息交換，設計出適用於強化資通系統之安全機制，不僅符合機密性、完整性、不可否認性等基礎

安全需求外，並能抵禦常見之竊聽及偽冒等網路攻擊手段，更可建立運算速度快，耗費資源少之保護機制，兼顧效能、成本與安全性，有效地防杜機敏訊息失竊風險。